Have you been wanting help losing weight, but don’t want the side effects of a medication? Or, perhaps you are currently taking a weight loss medication, but you wish to transition away from it without regaining the weight. Meet CaloCurb, Your Weight Loss “Off-Ramp”.
CaloCurb is a completely plant-based, non-toxic nutraceutical clinically shown to support weight management. It can be used alone or alongside GLP-1s, offering flexibility for your health journey.
And, the clinical dose of Calocurb is only $119.99 per month! This is a fraction of the cost of prescription medications.
The Science Behind CaloCurb
Funded by a $20 million research grant from the New Zealand government, CaloCurb represents the largest government-funded nutraceutical weight-loss trial ever conducted. The research initially aimed to map bitter-taste receptors in the human gut to naturally trigger the release of appetite-suppressing hormones. This work led to the discovery of Amarasate®, a standardized Humulus lupulus (bitter hops) extract, which became the first GLP-1-indicated nutraceutical in 2019.
Clinical evidence shows:
- Reduced caloric intake by 18%, comparable to the 24% reduction observed in the STEP 1 trial for Ozempic
- Increased endogenous GLP-1 and CCK secretion six-fold, roughly doubling normal post-meal hormone release
- Decreased hunger by 30% and food cravings by 40% in both men and women
- Improved post-prandial glucose control without raising insulin
- Effects observed within one hour of dosing, lasting 4–6 hours, in sync with natural gut hormone rhythms
CaloCurb Clinical doubles the Amarasate® concentration compared to retail formulas (250 mg vs 125 mg), enhancing GLP-1 and CCK output for stronger appetite control.
How CaloCurb Differs From GLP-1 Medications
While both CaloCurb and injectable GLP-1 receptor agonists support weight loss, their mechanisms are distinct:
| Feature | CaloCurb Clinical | Injectable GLP-1 RAs |
| Mechanism | Activates TAS2R bitter-taste receptors on gut cells | Acts indirectly through the bloodstream to stimulate L-cells |
| Onset | ~1 hour | Delayed, over several hours/days |
| Duration | 4–6 hours, aligns with natural post-meal rhythm | Weeks-long, supra-physiologic levels |
| Digestive Impact | Resets digestion overnight, avoids bloating/nausea | Slowed gastric emptying can cause GI side effects |
| Safety | 100% plant-based, GMO-free, stimulant- and caffeine-free | Prescription drug with potential systemic side effects |
CaloCurb’s targeted gut receptor activation helps your digestion “reset” naturally, minimizing nausea, bloating, and constipation often seen with weekly GLP injections.
Safe, Effective, and Convenient
CaloCurb Clinical is manufactured in a TGA-, NSF-, and FDA-approved facility under GMP standards. Its delayed-release Licaps® technology ensures intestinal, rather than gastric, delivery, targeting appetite-control pathways without stimulating appetite. With less than 1% systemic bioavailability, it minimizes interactions with the liver or kidneys.
How to use CaloCurb:
- Take two capsules per day, one hour before meals on an empty stomach with water
- Use as a stand-alone supplement, an off-ramp for GLP-1s, or as part of intermittent fasting, time-restricted eating, or perimenopausal appetite control protocols
Complement Your Weight Loss Journey
If you’re still using GLP-1 medications, check out our GLP Rx program here: [link to OpenLoop blog].
For those tapering off GLPs, remember: it can take up to six months to regain natural GLP-1 production. CaloCurb can help increase your body’s own satiety hormones, making the transition smoother and you can avoid rebound weight gain.
Common Challenges with GLP-1 Medications
Many patients report:
- Weight loss occurs in unintended areas (e.g., muscle instead of abdominal fat)
- Digestive issues such as bloating, nausea, or constipation
- Muscle loss and bone density loss
- Skin laxity due to rapid weight loss
Using Calocurb instead of, or as a transition away from, prescription medications could be exactly the right answer for you.
Try Our Evidence-Based Weight Loss Bundle
We offer a weight loss bundle powered by clinically tested nutraceuticals for less than the cost of a GLP-1 prescription alone. Whether your goal is to transition off GLPs, microdose them, or go fully natural, this bundle supports your weight management journey safely and effectively.
Support tools we recommend alongside CaloCurb for optimal results:
- Creatine – supports lean muscle mass synthesis and muscle protein production
- Reducore – helps reduce insulin resistance and glucose absorption, preventing blood sugar spikes
- Mitocore – a robust multivitamin that supports cellular-level health and enhances mitochondrial function
With this robust set of supplements, your monthly cost is still lower than the cost of prescription medications alone. And these supplements allow your body to increase its own supply of the satiety-inducing substance, GLP.
Your body is meant to be strong, lean, and agile. These products can help you on that path.
Email us at office@capitalhealthiowa.com if you’d like to try Calocurb or the weight loss bundle.